Difference between revisions of "Leukocytoclastic vasculitis"

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==2013-06-27: *Deep breath*==
 
==2013-06-27: *Deep breath*==
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{{quote|quote=&nbsp; Leukocytoclastic vasculitis is the most common form of small-vessel necrotizing vasculitis[...]<br />&nbsp; The characteristic lesions are referred to as palpable purpura.  The lesion begins as a localized area of cutaneous hemorrhage that acquires substance and becomes palpable as blood leaks out of damaged venules. Nodules, bullae, and ulcers may arise from these purpuric areas and indicate more severe vessel imflamation and necrosis[...]<br />&nbsp; Prodromal symptoms include fever, malaise, myalgia, and joint pain.  Small lesions itch and are painful; nodules, ulcers, and bullae may be very painful.<br />&nbsp; Lesions appear in crops and last 1 to 4 weeks. Recurrences are common and new crops may appear for weeks, months, or years.|book=Clinical Dermatology: A Color Guide to Diagnosis and Therapy|reference=page 376|width=50%}}
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Today is my father's birthday and I wanted to call him to say hi, however, I know he's going to ask me if I'm coming to the annual family get-together, and I need to
 
Today is my father's birthday and I wanted to call him to say hi, however, I know he's going to ask me if I'm coming to the annual family get-together, and I need to
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Go to an ER now!
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secondary infection
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Sick Leave
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Rash on back and arms, abdomen
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stages (rash/itch, purpura/sensitivity, RLS from hell (acid needle), oozing/ice pick hypersensitivity
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hypersensitivity, screaming
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malaise, insomnia
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Scare with bloody underwear
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Ulcerations
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blood in all pieces of clothing.... *sigh*
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  bloody socks are a regular thing.
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===Biopsy results===
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{{quote|quote=COMMENT: THE HISTOLOGIC CHANGES SUGGEST A MIXED VASCULITIC PROCESS OF MEDIUM AND SMALL-SIZED BLOOD VESSELS WITH SOME AREAS THAT ARE LEUKOCYTOCLASTIC IN OTHERS WHICH ARE LYMPHOID.  THE SECOND TISSUE SAMPLE FRAGMENT HAS BEEN SUBMITTED FOR IMMUNOFLUORESCENCE STUDIES WHICH WILL BE CORRELATED IN AN AMMENDMENT TO THIS REPORT|reference=Surgical Pathology Report|width=50%}}
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{{quote|quote=The findings are non-specific and do not follow a recognizable pattern of immunopathological disease.|reference=Dermatopathology Report *Amended*|width=50%}}
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Translation: "Yeah, it's leukocytoclastic vasculitis, but we don't have a clue what's causing it."  The rheumatologist gave the analogy of being set down from a balloon in the middle of a cornfield.  You know you are in a cornfield, but you do not have the faintest notion where the cornfield is.
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===Epidemiology===
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The occurrence of Leukocytoclastic vasculitis in adults is rare. Studies in [http://www.ncbi.nlm.nih.gov/pubmed/10693883 the UK], and [http://ard.bmj.com/content/60/2/170.short Spain] have shown a rate of about 20 adults per million per year.  Anecdotally my dermatologist sees about ten cases per year and my rheumatologist has seen about 10 cases in his entire career.  While a tthe surface these seem contradictory, it's not.  The dermatologist's numbers include children where it is known as [http://en.wikipedia.org/wiki/Henoch-Sch%C3%B6nlein_purpura Henoch-Schönlein purpura].  Dermatologists are usually the first line of defense and the condition is usually only referred to a rheumatologist when it becomes apparent that it is likely chronic.  In children, the condition usually goes away quickly and is rarely chronic.
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{{:leukocytoclastic_vasculitis_images}}
 
{{:leukocytoclastic_vasculitis_images}}

Revision as of 19:44, 27 June 2013

Left leg 2013-03-17, the day before my birthday. I didn't photograph my other leg at the time because I was just trying to show mom the LV itself, not the secondary infection that had set in on the right leg. Also, I was in intense pain, so I wasn't exactly thinking about chronicling.
This article is a stub. I'll get around to lengthening it when I feel like it :)

TL;DR

For the TL;DR crowd: In February I developed a condition called leukocytoclastic vasculitis, which is essentially a disease where the immune system decides your blood vessels are foreign invaders and attempts to destroy them. It appears to be chronic, however, there doesn't appear to be internal organ involvement, and it looks like we're finally getting it under control with oral steroids.

2013-06-27: *Deep breath*

  Leukocytoclastic vasculitis is the most common form of small-vessel necrotizing vasculitis[...]
  The characteristic lesions are referred to as palpable purpura. The lesion begins as a localized area of cutaneous hemorrhage that acquires substance and becomes palpable as blood leaks out of damaged venules. Nodules, bullae, and ulcers may arise from these purpuric areas and indicate more severe vessel imflamation and necrosis[...]
  Prodromal symptoms include fever, malaise, myalgia, and joint pain. Small lesions itch and are painful; nodules, ulcers, and bullae may be very painful.
  Lesions appear in crops and last 1 to 4 weeks. Recurrences are common and new crops may appear for weeks, months, or years.
Clinical Dermatology: A Color Guide to Diagnosis and Therapy, page 376 



Today is my father's birthday and I wanted to call him to say hi, however, I know he's going to ask me if I'm coming to the annual family get-together, and I need to

Go to an ER now! secondary infection Sick Leave Rash on back and arms, abdomen stages (rash/itch, purpura/sensitivity, RLS from hell (acid needle), oozing/ice pick hypersensitivity hypersensitivity, screaming malaise, insomnia Scare with bloody underwear Ulcerations blood in all pieces of clothing.... *sigh*

 bloody socks are a regular thing.


Biopsy results

COMMENT: THE HISTOLOGIC CHANGES SUGGEST A MIXED VASCULITIC PROCESS OF MEDIUM AND SMALL-SIZED BLOOD VESSELS WITH SOME AREAS THAT ARE LEUKOCYTOCLASTIC IN OTHERS WHICH ARE LYMPHOID. THE SECOND TISSUE SAMPLE FRAGMENT HAS BEEN SUBMITTED FOR IMMUNOFLUORESCENCE STUDIES WHICH WILL BE CORRELATED IN AN AMMENDMENT TO THIS REPORT
Surgical Pathology Report 


The findings are non-specific and do not follow a recognizable pattern of immunopathological disease.
Dermatopathology Report *Amended* 


Translation: "Yeah, it's leukocytoclastic vasculitis, but we don't have a clue what's causing it." The rheumatologist gave the analogy of being set down from a balloon in the middle of a cornfield. You know you are in a cornfield, but you do not have the faintest notion where the cornfield is.

Epidemiology

The occurrence of Leukocytoclastic vasculitis in adults is rare. Studies in the UK, and Spain have shown a rate of about 20 adults per million per year. Anecdotally my dermatologist sees about ten cases per year and my rheumatologist has seen about 10 cases in his entire career. While a tthe surface these seem contradictory, it's not. The dermatologist's numbers include children where it is known as Henoch-Schönlein purpura. Dermatologists are usually the first line of defense and the condition is usually only referred to a rheumatologist when it becomes apparent that it is likely chronic. In children, the condition usually goes away quickly and is rarely chronic.